Pharmacokinetics of meropenem in subjects with various degrees of renal impairment
نویسندگان
چکیده
منابع مشابه
Clinafloxacin pharmacokinetics in subjects with various degrees of renal function.
As the primary route for elimination of clinafloxacin is renal clearance (CL(R)) of unchanged drug, studies were conducted to determine the pharmacokinetic profile of clinafloxacin following administration to young and elderly subjects, subjects with various degrees of renal function, and subjects requiring dialysis. These were open-label studies in which subjects received single oral clinaflox...
متن کاملPharmacokinetics of meropenem in patients with various degrees of renal function, including patients with end-stage renal disease.
The pharmacokinetics of meropenem were studied after intravenous infusion in 13 patients grouped according to the impairment of their renal function. Creatinine clearance (CLCR) was greater than 50, 50 to 30, and less than 30 ml/min in groups I, II, and III, respectively. Two other groups, groups IV and V, each comprising four patients with end-stage renal disease (CLCR, < 5 ml/min), were also ...
متن کاملPharmacokinetics of telbivudine in subjects with various degrees of hepatic impairment.
This study evaluated the effect of hepatic impairment on the pharmacokinetics of telbivudine, an investigational nucleoside antiviral for the treatment of chronic hepatitis B virus infection. Twenty-four subjects were assigned to four hepatic function groups (normal function and mild, moderate, and severe impairment, with six subjects in each group) on the basis of Child-Pugh scores. The subjec...
متن کاملEvaluation of the Single-dose Pharmacokinetics of Bilastine in Subjects with Various Degrees of Renal Insufficiency
BACKGROUND Bilastine is a novel second-generation H1 antihistamine, which has not shown sedative or cardiotoxic effects in clinical trials and in post-marketing experience so far, developed for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria. It has recently been granted marketing authorization for these therapeutic indications in adults and adolescents at a once-daily o...
متن کاملPharmacokinetics of piperacillin in subjects with various degrees of renal function.
The pharmacokinetics of piperacillin were examined after single intravenous doses to three groups of male patients with creatinine clearances of greater than or equal to 60 (group I), greater than or equal to 20 but less than 60 (group II), and less than 20 (group III) ml/min per 1.73 m2. Each of 32 patients received either 1 or 4 g of piperacillin as a bolus injection. Three patients received ...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1992
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.36.7.1532